Pfizer’s novel NGF pain drug is potential game changer
 
 Phase II clinical trials of tanezumab in osteoarthritis, chronic low back pain and interstitial cystitis have demonstrated the drug’s analgesic efficacy across these three chronic pain settings. Despite safety concerns and a high price point, it expects tanezumab to delight in a significant first-in-class advantage in a potentially lucrative novel area of pain therapy. ( http://www.bharatbook.com/detail.asp?id=130154&rt=Stakeholder-Insight-Osteoarthritis-Drug-development-lags-behind-rising-osteoarthritis-population.html )
 
 Pfizer has announced positive results from three Phase II trials in pain at the American Academy of Pain Medicine’s 26th Annual Meeting. The randomized, double-blind, placebo-controlled six-week trials in patients with chronic low back pain (CLBP) and interstitial cystitis receiving a single intravenous infusion of tanezumab (200mcg/kg) met their primary endpoints of significantly superior pain relief over placebo. The CLBP study also included a third treatment group receiving naproxen twice daily, and tanezumab showed a greater analgesic effect than this competitor. In the 16-week osteoarthritis trial, patients were randomized to received tanezumab (10mcg/kg, 25mcg/kg, 50mcg/kg, 100mcg/kg or 200mcg/kg) or placebo. All doses of the drug achieved a reduction in pain while at the same time demonstrating a favorable safety profile.
 
 It estimates that 140 million people suffer from chronic pain across the seven major markets (the US, Japan, France, Germany, Italy, Spain and the UK). Chronic pain treatments include narcotic analgesics and non-steroidal anti-inflammatory drugs (NSAIDs); but, these therapies suffer from high abuse potential and limited efficacy. Given that pain will become more prevalent in the future due to the aging population, the chronic pain market continues to represent an attractive commercial opportunity for pharmaceutical developers.
 
 Tanezumab is a humanized monoclonal antibody (mAb) against nerve growth factor (NGF) and is in position to become Pfizer’s first pain medication since its neuropathic pain treatment Lyrica (pregabalin) was approved in 2005. With strong efficacy demonstrated in different pain settings, the drug is expected to be the first major novel therapy in the management of pain for a number of years. But, while tanezumab offers excellent evidence as a ‘proof of concept’ that interfering with the NGF pathway provides an analgesic effect, strong competition exists in the pipeline: Johnson & Johnson’s JNJ-42160443; Sanofi-Aventis’ and Regeneron’s Phase II drug REGN475; and Abbott’s PG110, which entered Phase I clinical trials in mid-2009.
 
 Although the NGF class uses a novel mechanism for the treatment of pain, it believes that drug safety profiles may limit the patient population. Adverse events documented thus far include an abnormal peripheral sensation (tingling and numbness) and muscle aches. Moreover, given that NGF is involved in the development of the nervous system, reproductive toxicology issues will prevent its use in women of childbearing age. Another limiting factor could be cost: It expects that these therapies will be priced similarly to the biologics available to treat rheumatoid arthritis, and as such will be far more expensive than existing pain treatments. This will lead to insurance companies effectively forcing clinicians to try current therapies first, with NGF drugs held back as last-line alternatives.
 
 With the investment made by major pharmaceutical companies, the success of tanezumab (and that of the whole NGF class) will be dependent on the characterized risk-benefit profile. Phase II data suggest efficacy in a number of pain conditions. But, at present no patient has received at least a year’s treatment with tanezumab, so its long-term safety profile remains unknown. its recommends that NGF drug developers also pursue indications in acute pain, in case the chronic use of these therapies proves intolerable. With the pain market totaling .4 billion in 2008 across the seven major markets and the lack of efficacious pain treatments, NGF drugs could capture a considerable proportion of this market. Following analysis of Phase III trials that are due to end in 2011, it anticipates the launch of tanezumab in 2012 as the first biologic for the management of pain.
 
 Related research
 
 • Stakeholder Opinions: Back Pain – Gain competitive edge by targeting subpopulations
 http://www.bharatbook.com/detail.asp?id=98237&rt=Stakeholder-Opinions-Back-Pain-Gain-competitive-edge-by-targeting-subpopulations.html
 
 • Stakeholder Insight: Osteoarthritis – Drug development lags behind rising osteoarthritis population priced
 http://www.bharatbook.com/detail.asp?id=130154&rt=Stakeholder-Insight-Osteoarthritis-Drug-development-lags-behind-rising-osteoarthritis-population.html
 
 • Pfizer Inc.: PharmaVitae Profile
 http://www.bharatbook.com/detail.asp?id=70276&rt=Pfizer-Inc-PharmaVitae-Profile.html
 
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You know what it feels like when out of the blue your back suddenly seizes in debilitating pain and it’s all you can do to keep from falling to the floor. That’s what acute back pain is, a sudden sharp and severe intense pain that comes on unexpectedly and quickly. This is unlike chronic back pain which is more continuous or constant. Fortunately there are ways to find relief for acute back pain that will help the symptoms until you can get proper medical treatment.

For anyone who has suffered acute back pain you know how hard it can make everyday tasks. This type of pain is normally caused by some sort of injury to the back but can also be caused by other chronic conditions that have been left untreated. It is the type of pain that is hard to ignore and the best advice anyone can give it to schedule an appointment with your doctor to get the right treatment.

There are several things you can do for back pain relief before you see your doctor or even while you are letting your back heal. The most vital thing to do is to try and keep your spine in a neutral position at all times. This means you want to keep the natural curvature of the spine intact. You can do this by using a lumbar role when sitting and by making a conscious effort to avoid slouching. When sitting it is also a excellent thought to use an ergonomically designed chair that offers excellent support. Avoid “comfy” furniture that is soft and offers small support as this can really cause the pain to worsen.

If you need to drive or ride in a car there are a couple of things you can do to make the ride less painful. The lumbar role that you use around the house can also be used in the car to keep you spine in a neutral position. If you are driving consider moving the seat back to make you arms straighter when holding the steering wheel. This keeps the whole body in a more upright posture relieving the stress on your back.

Making the injury worse is the last thing you want to do if you are looking for back pain relief. Lifting anything heavy, or even a light load, should be avoided to keep from further aggravating the problem. Another thing you don’t want to do is sleep on a soft bed as it will not support the back and lengthen the healing process.

That is the key to any type of back pain relief from an injury or other condition, giving it a chance to heal. Of all the parts of the body the back can take an inordinate amount of time to heal. Trying to rush back into your ancient routine will only make the problem worse and take that much longer to get better.

Hemorrhoids are painful protrusions in your anus that are also oftentimes itchy.  Although there are over-the-counter medicines you can apply to the area, these medicines only alleviate the pain and discomfort temporarily.  When you want to place an end to your pain and discomfort, learn how to cure hemorrhoids naturally.

The Symptoms

A painful protrusion in the anal area is the primary symptom of hemorrhoids.  This is accompanied by itching and burning sensation.  In some instances, you may also see red streaks in the toilet paper or bowl. This is when you have a bleeding hemorrhoid.  How painful the hemorrhoid is depends on how severe the problem is.  Although hemorrhoid is not a threatening health issue, it is still vital to deal with it as early as possible if only to get rid of the pain you experience from the condition.

The Cause

Hemorrhoid is an offshoot of one or a combination of factors.  These factors have one thing in common: they place added pressure on the veins in the anal area that cause the veins to swell and protrude.  The condition can be aggravated further when you sit on the toilet bowl for a long period of time, trying to go your bowel.  The factors that add pressure to the anus include constipation, sitting or standing for long periods of time, pregnancy, and anal sex.

The Treatment

You are familiar with the over-the-counter medications that you use as treatment for hemorrhoids.  In severe cases, physicians may recommend the removal of hemorrhoids through surgery.  But these treatments are only temporary in nature and do not really solve the problem.  To cure hemorrhoids with lasting results, you need to address it at its root.  The safest way to do this is to learn the natural cures for hemorrhoid.

The Solution

Natural cures for hemorrhoid are what you need to get rid of your problem permanently.  With this natural approach, you can save yourself from unnecessary exposure to health risks that other treatments may bring.  You can also save on time and cost while having the guarantee that you can cure hemorrhoids effectively, safely, and quickly.  Place an end to your pain right now.

More Pain questions please visit : HealthCareAsk.com

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A sudden spasm come over my knees, what is incorrect near it?
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A TATOO BEHIND EAR, OR FRONT WRIST?
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Back pain is one of the world’s most common ailments, afflicting most people at least once in their lifetime. There are several types of back pain and various options for back pain relief. Back pain becomes more likely the older we get due to the degenerative effects of aging. But, lifestyle choices and right posture can make a huge difference in our chances for developing serious back pain.

Lower back pain is the most common type of back pain. One study reported that in the United States alone low back pain was responsible for the loss of 93 million workdays per year, with a health care cost of more than five billion dollars. Low back pain is most often caused by some sort of injury or overuse of your muscles. Most lower back pain clears up on its own in a few days. Rest, hot or cold compresses and over-the-counter medications are usually the only treatment required to provide low back pain relief.

Middle back pain can result from injury that strains the muscles or ligaments. This can occur when you’ve engaged in excessive exertion or heavy lifting. Middle back pain can also be caused by spinal conditions or other internal conditions. Any middle back pain that lasts longer than a few days or which is accompanied by other symptoms could be warning you of a serious condition. You should seek medical advice as soon as possible.

Upper back pain is honestly uncommon, though not unheard of. The upper back is really quite different from the lower back both in the way it’s place together and the functions it’s designed to perform. The upper back is normally very strong. The strength of our upper back is how we are able to stand upright. It’s also designed to provide protection for the vital organs located in our chest area. The upper back is extremely stable and has only limited mobility. This is why injuries and degeneration are rare in the upper back area. When upper back pain does occur, it’s normally due to irritation of the muscles or joint problems. Herniated discs in the upper back region are extremely rare, though not impossible.

Chronic back pain is defined as back pain that has lasted for twelve weeks or longer. Chronic back pain can be irritating for some and agonizing for others. In some cases, the severity of chronic back pain makes normal life nearly impossible. As many as five million Americans report at least a partial disability due to chronic back pain, and an additional two million face pain so severe that they are unable to work.

Lifting heavy items improperly is the most common cause of back pain. Always remember: “lift with your legs, not with your back.” Most medical professionals recommend sleeping on your side. A firmer mattress is better than a soft one. For added comfort, sleep with a pillow between your knees. When you reach for something on the ground, squat down to pick it up instead of bending at the waist.

Stretching exercises and maintaining flexibility is the best prescription for avoiding serious back pain. Your doctor should be able to recommend some excellent exercises. Surprisingly, you should also work to strengthen your abdominal muscles. Strong abs will reduce the strain on your back.

There’s always the possibility that accidents will happen, and no one can avoid aging. But with attention to posture, caution when lifting and minor lifestyle changes, you should be able to significantly reduce your risk for severe back pain.