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Will Plastic Surgery Turn You Into an Addict?


Will Plastic Surgery Turn You Into an Addict?


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Home Page > Health > Anti Aging > Will Plastic Surgery Turn You Into an Addict?

Will Plastic Surgery Turn You Into an Addict?

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Posted: May 19, 2010 |Comments: 0
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 ”I don’t feel prettier, I don’t feel younger. I just feel scarred.” 

These are the words from Laura Perella, the author of Chasing Beauty, her cautionary tale of the toll chasing beauty through plastic surgery took on her life.

Laura chose to have fifteen surgeries from age 25 to age 35, and spent ,000 hoping to improve her already God-given excellent looks. She now warns others who might be swayed into believing that surgery and injections will stave off Mother Nature’s tromp across their faces that they might meet up with the same terrible plastic surgeons she hired. Today at 39 years of age, she shares her plight: “I don’t feel prettier, I don’t feel younger. I just feel scarred.”

Laura is probably the exception because most patients do not undergo quite so many procedures. She encourages young women to seek other modalities because chasing beauty through plastic surgery takes a toll on your body, your excellent looks and certainly your bank account.

You know, Laura is not alone because many plastic surgery users have spoken out regarding their disappointment with their surgical results. One plastic surgeon remarked that ‘Plastic surgeon’ has been called a psychiatrist with a scalpel. More aptly plastic surgeons are not the magicians their clients wish they were. There are wonderfully trained surgeons but unrealistic expectations and surprises can derail even the best procedure.

What women want is a younger looking face. One that is toned and tightened. They want natural beauty, not man-made, cookie-cutter features.

If you choose surgery and injections these methods may produce disappointing results; surgery is perilous business and yes, cosmetic procedures are indeed surgery. Tummy tucks, liposuction, facelifts, eye lifts, jowls lifts, neck lifts all require sedation and cutting.

Using injections to plump nasal labial folds, lips and more can also produce disappointing results; allowing injections of toxins and chemicals to paralyze your facial muscles also have drawbacks like making droopy eye brows and bunny wrinkles alongside your nose. What? More wrinkles?

Yes, when you paralyze one part of your face, your surrounding muscles must compensate for the paralysis. The paralysis primarily immobilizes a particular muscle but studies show that there is migration of the serum especially when it is injected into the face – namely it migrates to your brain.

The warnings include the usual superfluous ones like swelling, redness at the injection site and maybe a droopy eyelid that will probably right itself in a few weeks – certainly in less than three months.  The very telling danger lies in the words of caution such as:

Paralysis of a nearby muscle that could interfere with opening the eye(s)
Disorientation, double vision or past pointing (dizziness or imbalance)
Temporary asymmetrical appearance
Abnormal or lack of facial expression
Local numbness
Headache, nausea or flu-like symptoms
Swallowing, speech or respiratory disorders
Facial pain
Product ineffectiveness
Muscle atrophy
Nerve irritability           
Production of antibodies with unknown effect to general health
Death
Serious disability

Some of the most unusual authorization aspects are the statements that a patient must agree to if they choose Botox:

I am aware and accept that no guarantees about the results of the procedure have been made or implied.
I know and accept that the long-term effects of repeated use of Botox Cosmetic are as yet unknown. 

The effects of Botox are temporary yet the effects can cause long-lasting side effects.

Just so you know other injections that plump up the grooves in your face and deflated lips have no long term testing either so if you are disappointed that your results do not meet your expectations you might want to consider non-invasive methods.

Choosing surgery and injections cost a lot of money and long-term use may place your heath at risk. Is this excellent common sense? Yes, injections are less radical than surgery but over time there can be complications. Remember, there has been no long-term testing on any injection used for cosmetic purposes.

So what can stop the downward slide of your face? 

Specialized facial exercises act as a preventative measure and also help reverse the look of aging in your face. Just as exercise works for your body, facial exercise techniques that isolate, anchor and contract the muscles using gloved thumbs and fingers will lift, tone and tighten sagging facial muscles in hardly any time at all.

 A sagging face is a result of soft, lax, droopy muscles. The facial skin is attached directly to the tiny, hidden muscles so when these muscles elongate from lack of use, they drag your skin downward, making wrinkles that add to the look of ancient.

Most facial exercise users like their results and will tell you that their new faces developed slowly but surely when they dedicated themselves to exercising regularly. Facial exercise doesn’t take much time but the results can be startling. Imagine, your face looking 10 -15 years younger without one stitch or injection. Using thumbs and fingers and armed with the knowledge that you can make a younger looking face that everybody notices, you’ll never have to worry about an addiction to surgery or injections.

www.rejenuve.com/FacialMagicSL.htm

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Cynthia Rowland -
About the Author:

Cynthia Rowland is widely recognized as an expert in all natural facial fitness. She has appeared on The View, The Today Show, Rachael Ray, The Doctors and other well loved shows. Cynthia is co-host of The Ageless Sisters on blogtalkradio.com and author of The Magic of Facial Exercise. This author, speaker and television personality is leading the crusade to keep men and women looking vibrantly younger through natural techniques without spending their children’s inheritance. You may learn more about her anti-aging techniques at www.rejenuve.com/FacialMagicSL.htm and she welcomes your subscription to her FREE content rich newsletter at http://cynthiarowland.com/newsletter-signup.php 

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Posted in Back Pain ProductsComments (0)

Stakeholder Opinions: Targeting Nerve Growth Factor for Pain Therapy – Groundbreaking class to breathe new life into saturated market


Introduction

Pain treatment is a multibillion dollar market that is saturated with a wide variety of branded and generic drugs. The NGF class has potential to be first of an entirely new type of painkiller to enter the sector in decades. Nevertheless, high expectations need to be tempered once the long term side effects, safety and pharmacoeconomics have been established.

Scope

*Overview of the current chronic pain market including epidemiology and key unmet needs.

*In depth analysis of the NGF class in development and proposed positioning in the treatment algorithm.

*Insights from interviews with five leading US and European key opinion leaders about the potential impact of NGF therapies.

*Identification of drivers and resistors to the commercial success of NGF therapies.

Highlights

Clinical studies have shown inhibition of nerve growth factor (NGF) has a strong analgesic effect. Three classifications block or sequester the NGF signal transduction pathway; NGF antagonists, tropomyosin-related kinase A inhibitors and NGF trap molecules. The most advanced pipeline candidate is Pfizer’s tanezumab with expected launch in 2012.

The safety of the NGF targeting therapies remains uncertain. Adverse effects shown in tanezumab trials indicate peripheral neuropathy, dysesthesia and paresthesia were the most frequent, but, no patient has taken tanezumab for longer than 6 months. Further long-term trials are required to establish the risk-benefit profile in chronic usage.

The involvement of Huge Pharma will aid the successful long-term commercialization of NGF therapies. Not only do these companies have the resources necessary to conduct the large long-term clinical trials required for chronic pain therapy, but their activity and experience in licensing pain products will encourage higher uptake upon launch.

Reasons to Buy

*Know the development of the NGF class and quantify pipeline.

*Identify where the NGF class will be positioned in the market as determined by interviewed key opinion leaders.

*Evaluation of the commercial considerations which will drive or inhibit the success and impact of the anti-NGFs.

Table of Contents :

“Overview 1
Catalyst 1
Summary 1
ABOUT  HEALTHCARE 2
About the central nervous system pharmaceutical analysis team 2
Executive Summary 3
Scope of the analysis 3
insight into the potential of nerve growth factor (NGF) for pain therapy 3
Related reports 5
Upcoming reports 5
Table of Contents 6
1. Pain – Market Potential 7
Key findings 7
Definition 8
Epidemiology 9
Chronic pain prevalence represents a substantial population 9
Back pain and arthritic conditions are the most prevalent chronic pain indications 12
Current treatment options 14
Management of chronic pain severity 16
Consequences of inadequately treated chronic pain 16
Current market overview 17
Unmet needs in pain management 18
Unmet need 1: improved efficacy in hard-to-treat pain conditions 19
Unmet need 2: abuse deterrent and abuse resistant approaches 20
Unmet need 3: safer pain management treatments 21
Unmet need 4: reduction in adverse effects 22
Target product profile versus current level of attainment 26
2. Class development 27
Key findings 27
Nerve growth factor has a key role in pain 28
Therapies targeting nerve growth factor (NGF) in pain 29
NGF antagonists 30
TrkA inhibitors 31
NGF trap molecules that compete with TrkA receptors 32
Pipeline overview 33
Strong presence of Huge Pharma in NGF pipeline 33
Key Nerve growth factor projects in development 34
Overview of NGF antagonists and Overview of TrkA inhibitors 34
Tanezumab (RN624; Pfizer) 35
Drug profile 35
Development overview 36
First Phase III studies to yield results in 2011 36
Promising Phase II data 38
Peripheral neuropathy and paresthesia documented in Phase II studies 41
Product positioning 41
Pfizer will obtain arthritis approval first 41
Tanezumab will be priced equivalent to existing biologics 42
SWOT analysis 43
REGN475 (SAR-164877, Sanofi-Aventis/Regeneron) 43
Drug profile 43
Development overview 44
JNJ-42160443 (formerly AMG403, Ortho-McNeil-Janssen Pharmaceuticals/Amgen) 45
Drug profile 45
Development overview 46
PG110 (hu-alphaD11, Abbott) 47
Drug profile 47
Development overview 48
Overview of TrkA inhibitors 48
BXL1H5 (huMNAC-13; BioXell/Cosmo Pharmaceutical SpA) 49
Drug profile 49
Development overview 50
3. Commercial considerations 51
Key findings 51
Key drivers to commercial success of the nerve growth factor (NGF) class 52
Driver 1: increased efficacy and long duration for NGF antagonists 52
Anti-NGF therapies exhibit stronger efficacy than NSAIDs 52
Long half-life represents more convenient dosing regimen 53
Driver 2: novel target in pain management 53
First novel class to enter pain management in decades 53
Validation of NGF pathway will increase development of small molecule inhibitors 54
Driver 3: strong investment in anti-NGF technologies 54
Entrance of Huge Pharma into the NGF pipeline will act as strong driver for R&D 54
Driver 4: limited abuse potential 55
Anti-NGF therapies offer no euphoric effects that could lead to misuse 55
Driver 5: innovation in technology 56
Improvement in monoclonal antibody technology will limit immunological response 56
Specificity of anti-NGF will limit adverse drug-drug interactions 56
Key resistors to commercial success of the nerve growth factor (NGF) class 57
Resistor 1: safety issues of chronic use unknown 57
Reproductive toxicology issues 57
Long-term safety profile unknown 58
Resistor 2: high pricing will affect reimbursement and positioning 59
NGF therapies will be priced at a premium 59
Insurance companies are likely to insist on last-line usage 60
Set up costs will limit coverage and increase costs 61
High price will restrict usage to last-line 62
Resistor 3: does not treat all pain indications 62
Efficacy is strong in inflammatory disorders compared to neuropathic indications 62
4. Case Study 64
Key findings 64
Will anti-NGFs mirror the impact of anti-TNFs? 65
Similar to anti-TNFs, anti-NGFs will become the first biological drugs in chronic pain 65
Unlike anti-TNF, anti-NGFs will remain the last-line therapeutic choice if cost remains high 66
Less unmet need in chronic pain will result in lower anti-NGF uptake 69
Anti-NGFs will be priced the same as anti-TNFs 71
Proof of concept will open doors to increased competition 71
Anti-NGF usage will also spread to other indications 72
Bibliography 74
Journals 74
Websites 77
reports 79
Presentations 79
Appendix A 80
Data definitions, limitations and assumptions 80
Standard units 80
Appendix B 81
Contributing experts 81
Report methodology 81
About82
About  Healthcare 82
About the Central Nervous System analysis team 83
Disclaimer 85

For more information please visit :

http://www.aarkstore.com/reports/Stakeholder-Opinions-Targeting-Nerve-Growth-Factor-for-Pain-Therapy-Groundbreaking-class-to-breathe-new-life-into-saturated-market-45178.html

Posted in Back Pain ProductsComments (0)


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