Pfizer’s novel NGF pain drug is potential game changer
 
 Phase II clinical trials of tanezumab in osteoarthritis, chronic low back pain and interstitial cystitis have demonstrated the drug’s analgesic efficacy across these three chronic pain settings. Despite safety concerns and a high price point, it expects tanezumab to delight in a significant first-in-class advantage in a potentially lucrative novel area of pain therapy. ( http://www.bharatbook.com/detail.asp?id=130154&rt=Stakeholder-Insight-Osteoarthritis-Drug-development-lags-behind-rising-osteoarthritis-population.html )
 
 Pfizer has announced positive results from three Phase II trials in pain at the American Academy of Pain Medicine’s 26th Annual Meeting. The randomized, double-blind, placebo-controlled six-week trials in patients with chronic low back pain (CLBP) and interstitial cystitis receiving a single intravenous infusion of tanezumab (200mcg/kg) met their primary endpoints of significantly superior pain relief over placebo. The CLBP study also included a third treatment group receiving naproxen twice daily, and tanezumab showed a greater analgesic effect than this competitor. In the 16-week osteoarthritis trial, patients were randomized to received tanezumab (10mcg/kg, 25mcg/kg, 50mcg/kg, 100mcg/kg or 200mcg/kg) or placebo. All doses of the drug achieved a reduction in pain while at the same time demonstrating a favorable safety profile.
 
 It estimates that 140 million people suffer from chronic pain across the seven major markets (the US, Japan, France, Germany, Italy, Spain and the UK). Chronic pain treatments include narcotic analgesics and non-steroidal anti-inflammatory drugs (NSAIDs); but, these therapies suffer from high abuse potential and limited efficacy. Given that pain will become more prevalent in the future due to the aging population, the chronic pain market continues to represent an attractive commercial opportunity for pharmaceutical developers.
 
 Tanezumab is a humanized monoclonal antibody (mAb) against nerve growth factor (NGF) and is in position to become Pfizer’s first pain medication since its neuropathic pain treatment Lyrica (pregabalin) was approved in 2005. With strong efficacy demonstrated in different pain settings, the drug is expected to be the first major novel therapy in the management of pain for a number of years. But, while tanezumab offers excellent evidence as a ‘proof of concept’ that interfering with the NGF pathway provides an analgesic effect, strong competition exists in the pipeline: Johnson & Johnson’s JNJ-42160443; Sanofi-Aventis’ and Regeneron’s Phase II drug REGN475; and Abbott’s PG110, which entered Phase I clinical trials in mid-2009.
 
 Although the NGF class uses a novel mechanism for the treatment of pain, it believes that drug safety profiles may limit the patient population. Adverse events documented thus far include an abnormal peripheral sensation (tingling and numbness) and muscle aches. Moreover, given that NGF is involved in the development of the nervous system, reproductive toxicology issues will prevent its use in women of childbearing age. Another limiting factor could be cost: It expects that these therapies will be priced similarly to the biologics available to treat rheumatoid arthritis, and as such will be far more expensive than existing pain treatments. This will lead to insurance companies effectively forcing clinicians to try current therapies first, with NGF drugs held back as last-line alternatives.
 
 With the investment made by major pharmaceutical companies, the success of tanezumab (and that of the whole NGF class) will be dependent on the characterized risk-benefit profile. Phase II data suggest efficacy in a number of pain conditions. But, at present no patient has received at least a year’s treatment with tanezumab, so its long-term safety profile remains unknown. its recommends that NGF drug developers also pursue indications in acute pain, in case the chronic use of these therapies proves intolerable. With the pain market totaling .4 billion in 2008 across the seven major markets and the lack of efficacious pain treatments, NGF drugs could capture a considerable proportion of this market. Following analysis of Phase III trials that are due to end in 2011, it anticipates the launch of tanezumab in 2012 as the first biologic for the management of pain.
 
 Related research
 
 • Stakeholder Opinions: Back Pain – Gain competitive edge by targeting subpopulations
 http://www.bharatbook.com/detail.asp?id=98237&rt=Stakeholder-Opinions-Back-Pain-Gain-competitive-edge-by-targeting-subpopulations.html
 
 • Stakeholder Insight: Osteoarthritis – Drug development lags behind rising osteoarthritis population priced
 http://www.bharatbook.com/detail.asp?id=130154&rt=Stakeholder-Insight-Osteoarthritis-Drug-development-lags-behind-rising-osteoarthritis-population.html
 
 • Pfizer Inc.: PharmaVitae Profile
 http://www.bharatbook.com/detail.asp?id=70276&rt=Pfizer-Inc-PharmaVitae-Profile.html
 
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Plantar fasciitis is a common, persistent foot injury that requires proper treatment. Plantar fascitis results in acute inflammation and severe pain in the fibrous band of tissue running across the bottom of the foot. Because the ligaments, tendons, and tissue in the foot go every time the foot is flexed, when they are inflamed, every movement hurts, making daily activities very painful.  Once the plantar fascia tissue is injured, 100% recovery is hard and re-injury occurs frequently. But, therapies such as ultrasound can hold the key to complete plantar fascia healing. And luckily, ultrasound technologies are advancing and new affordable and portable ultrasound machines are becoming available for home users.

Causes:

Because the plantar fascia can only stretch 102% of its length without tearing, the stress of an extremely active lifestyle can be too much. This condition of the foot is caused primarily from overloading and overuse in jobs that require a person to be on their feet all day, such as teachers and waitresses, to push heavy loads, such as shippers and construction workers, and to participate in vigorous sports, such as running, dancing, football and basketball. Plantar fasciitis is one of the top five most common foot and ankle injuries among professional athletes.

Poor biomechanics, foot muscle and/or ligament imbalances, and faulty foot structures can also contribute to the development of plantar fasciitis. Other causes include obesity and poorly supported shoes.

The inflammation in the arch of the foot experienced by plantar fasciitis suffers can also lead to an intense stabbing pain in the heel and eventually, heel spurs. For this reason, it is critical to properly treat an inflamed plantar fascia at the onset of the condition with ultrasound therapy or another modality.

Treatments:

The intense flare-ups of pain in the arch of the foot associated with plantar fascitis can be best managed through conservative, regular treatments. Patient education on how to treat plantar fasciitis and self-care are critical components in healing from plantar fasciitis. Patience is also key, as an inflamed plantar fascia can take six months to a year to completely recover.

By modifying daily activities and exercise, wearing properly fitting shoes, taping the feet, and massaging the foot arch, the acute inflammation of plantar fasciitis can be minimized. After strenuous activities, RICE (rest, ice, compress, elevate) is generally the prescribed procedure for plantar fascitis sufferers. But, for 100% injury recovery, using therapeutic ultrasound prior to RICE treatment is best because the ultrasonic waves efficiently decrease inflammation and relive pain for diagnosed or chronic plantar fasciitis within the first 48 hours of a flare-up. Daily ultrasound physical therapy can be a very effective way to manage and heal plantar fasciitis and heel spurs and is best accomplished with a personal, therapeutic ultrasound device.

For those suffering from chronic plantar fasciitis, foot and tendon rehabilitation at home is now possible with the advent of portable ultrasound machines. The ultrasound therapy utilized by these devices can be used as an advanced treatment of plantar fasciitis and the chronic tendon pain that accompanies the condition. Therapeutic ultrasound can be used to reduce pain and heal foot and ankle injuries twice as quick.

Ultra sound waves provide gentle deep tissue heating that decreases pain and inflammation to speed healing by penetrating the skin and causing vibrations in the tendons and soft tissues of the foot. Ultrasound therapy relaxes muscles and decreases swelling by increasing blood flow and oxygen to tendons and ligaments. Ultrasound deep tissue stimulation can be used as a pain therapy system to control plantar fasciitis flare-ups and can now be used in the comfort of your very own home.

A home ultrasound unit works the same way as larger machines, found in physical therapist and chiropractor practices, but is more compact and priced reasonably so home users can afford to buy.  Portable ultrasound machines are also safe for use by the general public because they utilize pulsed, instead of continuous, ultrasound waves, which are just as effective when used on a daily basis. Plantar fasciitis physical therapy involving ultrasound will provide users with immediate relief and continual healing over a 3-4 week period.

Because plantar fascist involves soft tissue and tendon inflammation, a specific kind of home ultrasound machine is required for treatment. A home ultrasound physical therapy machine should emit 1Mhz ultrasound waves. It is also vital to buy an FDA approved ultrasound unit that is quality manufactured. The portable therapeutic ultrasound device should also be covered with at least a 1 year warranty. And best of all, with a portable therapeutic ultrasound machine, you can treat your plantar fasciitis daily when it is most convenient for you.

Fibromyalgia is a never-ending, health circumstance that is best described by defining its symptoms. These include, but certainly are not limited to: all-over body pain in the muscles, ligaments and tendons; numerous sore-to-the-touch areas on the body, or tender points, where even the slightest strain causes immense pain and recurrent tiredness even after lengthy sleep. The indications of Fibromyalgia can vary according to the time of day, weather, stress and/or physical activity. There are no medical tests for Fibromyalgia. Doctors must first rule out all other conditions that could be causing these symptoms before diagnosing a patient with Fibromyalgia.

Experts theorize that people with Fibromyalgia never truly reach the profound restorative phase of sleep, and that is where the exhaustion comes from. Those with the condition can sleep for extensive periods of time and still wake up feeling tired. A couple of sleep disorders associated with Fibromyalgia are Restless-Leg Syndrome and Sleep Apnea.

Experts have also come up with a theory of why those with Fibromyalgia feel pain. They believe those with the condition have a lower limit to pain because of heightened feelings in the brain to pain stimuli. They also believe that those with the condition have repetitive nerve stimulus that causes the brain to change. The brain simply overreacts to pain signs.

The intense, chronic pain and sensitivity in muscles and ligaments experienced by Fibromyalgia sufferers can be debilitating and persistent. Although more common in females, Fibromyalgia can happen to anyone and occur at any time. The largest obstacle with Fibromyalgia is that there is no known cure, which means a lifetime of pain relieving drugs, such as NSAIDS (Non-Steroidal Anti-Inflammatory Drugs) or other specialized medications. Such prescriptions can be expensive and have unpleasant side effects.

Other treatment options for Fibromyalgia include, hot and cold packs, stretching, regular exercise and ultrasound therapy. Therapeutic ultrasound for the treatment of fibromyalgia can provide deep tissue stimulation and pain relief. Ultrasound physical therapy can be a very effective way to manage the pain of Fibromyalgia.

Ultrasonic waves penetrate the skin to cause vibrations in tendons and soft tissues, providing gentle deep tissue heating that decreases pain and inflammation to speed healing. Ultrasound therapy increases blood flow and oxygen to tendons as well as relaxes muscles and decreases swelling. Ultrasound can be used as a pain therapy system to control Fibromyalgia pain flare-ups and can now be used in the comfort of your very own home.

Home ultrasound machines are now available for ultrasound Fibromyalgia treatments and rehabilitation. Visits to a chiropractor or physical therapist office for ultrasound physical therapy can be expensive and inconvenient, but it is now possible to rehab Fibromyalgia, and many other chronic injuries, in the comfort of your own home.

Because Fibromyalgia involves soft tissue inflammation, a specific kind of home ultrasound machine is required for treatment. A home ultrasound physical therapy machine should emit 1Mhz ultrasound waves. It is also vital to buy an FDA approved ultrasound unit that is quality manufactured. Your portable therapeutic ultrasound device should also be covered with at least a 1 year warranty.

Because these home ultrasound machines utilize pulsed ultrasound waves, they are very safe for use by the general public. Pulse ultrasound also is just as effective as continuous wave ultrasound that is used by doctors, but in home treatments will just be more often. With a portable therapeutic ultrasound machine, you can treat your bursitis daily when it is most convenient for you.

Reference: www.EZUltrasound.com

Back pain is normally the most common condition that is consulted to doctors here and abroad. People who are prone to back pains are those individuals who constantly lifts weights and whose line of work requires heavy labor. It may be caused by a strained muscle, tussled nerve endings, strained ligaments and herniated discs. But remember that, through the  back pain therapy it is possible to treat back pain.

A lot of people believed that surgery is the only way to treat back pains effectively. But, small did they know that there are conservative methods that you can take advantage of. The pain can be alleviated through a simple and less expensive  back pain therapy.

Here are some of those back pain therapies:

physical therapy
enzyme therapy
spa therapy
Percutaneous Intramuscular Electrothermal therapy
Acupuncture
Yoga

Among all those back pain therapies, Yoga and physical therapy exercises can help a lot in managing back pain. Because it includes stretching and strength-building exercises. These exercises help strengthen and loosen not only your lower back but adjacent muscles like the legs, buttocks and abdomen as well. Developing the said areas makes a stabilizing support on your back. Stretching various muscles and ligaments during back exercises helps maintain and gain flexibility and mobility.

For stretching exercises you need to do the following:

1. Lie on the floor and let the vertebrae in your back to align themselves.

2. Hold the position for one minute.

3. Stretch you arms backwards and overhead and let your hands fall to the floor.

4. Relax and hold the position for one minute. Next, you need to pull one knee towards your chest while extending your other knee.

5. Hold your position then repeat it to your other knee.

6. Then pull both of your knees upwards and hold them near your chest area for a few seconds.

7. Drop your feet back and then keep repeating the movement.

8. Do the exercise on regular and prolonged periods of time for substantial results.

Strength-building exercises, on the other hand, helps build your lower back and adjacent muscles. To perform this, you have to lie on the floor with your knees bent and your lower back gently pressed on the floor. At times, this exercise relieves lower back pains immediately. The part within your lower and middle back is commonly vulnerable to pain. In strengthening this area, you need to prop your feet while lying down. Then lift your lower back and buttocks from the floor.

You may also do some hyper-extensions to your back. These are reverse sit-ups done while leaning on an exercise ball or on a Roman chair. Strength-building exercises should be done at least three times a week in consistent basis to attain improvements.

You could certainly do those exercises together with a physical therapist sessions, Because physical therapists are trained individuals that specialize on making physical regimens on pain areas and specific injuries and focuses on their healing. An accredited physical therapist helps you increase flexibility, motion range and blood flow better from what general exercise and stretching could offer.

Back pain may seem to be just a small problem for most people. But, there are some who have ignored the back pains that they have been experiencing – only to find out that it further lead into a worse case. If you want to find out more on back pains and the importance of making ways to relieve them, visit: – www.backpainmanagement.wordpress.com

Dental Pain Therapy Area Pipeline Report contains detailed information on the dental pain drug pipeline. This report provides insight into the pipeline status of dental pain drugs by company and by stage as well as a summary of the latest news and developments in this area.

Scope of the report:

Each Therapy Area Pipeline Report provides the user with real detail on drug pipelines, by company and by stage, for each specific therapy area. The latest news, by company, also ensures that each report is fresh and up-to-date.

In addition to new developments and disease specific pipeline projects, each report also contains extensive information in tabular format on a company’s full product pipeline and products by phase of development with regard to the therapy area.

Full pipeline details, by stage, are provided and include detailed product descriptions, information on partnering activity plus clinical trial intelligence. Each Therapy Area Pipeline Report also provides detail on the top 20 companies with products in the early stage of development and the top 20 companies with products in the late stage of development. Finally, each report also provides a comparison with other major indications in the disease hub based on Marketed Products vs. Pipeline Products.

Key benefits

• Know a company’s strategic position by accessing detailed independent intelligence on its product pipeline for specific therapy areas.
• Keep track of your competitors and partners by better understanding their product pipeline.
• Monitor a company’s research effectiveness by determining pipeline depth and number of products in development by clinical phase for specific disease areas.
• Maintain a critical competitive advantage.

For more information, please visit :

http://www.aarkstore.com/reports/Dental-Pain-Therapy-Area-Pipeline-Report-14513.html

Or email us at press@aarkstore.com or call +919272852585